© 2007 Society of Systematic Biologists
Evidence for Time Dependency of Molecular Rate Estimates
Edited by Jack Sullivan: Associate Editor
1 Department of Zoology, University of Oxford Oxford, United Kingdom E-mail: simon.ho@zoo.ox.ac.uk (S.Y.W.H.)
2 Allan Wilson Centre for Molecular Ecology and Evolution, Massey University Palmerston North, New Zealand
3 Australian Centre for Ancient DNA, Earth and Environmental Sciences, University of Adelaide Adelaide, Australia
4 Department of Computer Science, University of Auckland Auckland, New Zealand
5 Bioinformatics Institute, University of Auckland New Zealand
Received November 10, 2006; Revised January 29, 2007; Accepted April 9, 2007
| The first 150 words of the full text of this article appear below. |
Long-term changes in the genetic composition of a population occur by the fixation of new mutations, a process known as substitution. The rate at which mutations arise in a population and the rate at which they are fixed are expected to be equal under neutral conditions (Kimura, 1968). Between the appearance of a new mutation and its eventual fate of fixation or loss, there will be a period in which it exists as a transient polymorphism in the population (Kimura and Ohta, 1971). If the majority of mutations are deleterious (and nonlethal), the fixation probabilities of these transient polymorphisms are reduced and the mutation rate will exceed the substitution rate (Kimura, 1983). Consequently, different apparent rates may be observed on different time scales of the molecular evolutionary process (Penny, 2005; Penny and Holmes, 2001). The substitution rate of the mitochondrial protein-coding genes of
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Response and Reanalysis |
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Case Study: Ancient Bison Sequences |
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Other Evidence for Time Dependency |
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Causes of Time Dependency |
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